Joseph C Wenke Selected Research

Open Fractures (Compound Fracture)

7/2022	Preclinical evaluation of a commercially available biofilm disrupting wound lavage for musculoskeletal trauma.
12/2020	Early application of topical antibiotic powder in open-fracture wounds: A strategy to prevent biofilm formation and infections.
12/2018	Topical rifampin powder for orthopedic trauma part I: Rifampin powder reduces recalcitrant infection in a delayed treatment musculoskeletal trauma model.
12/2017	An Effective Negative Pressure Wound Therapy-Compatible Local Antibiotic Delivery Device.
10/2016	Debridement and Irrigation: Evolution and Current Recommendations.
9/2015	Rifamycin Derivatives Are Effective Against Staphylococcal Biofilms In Vitro and Elutable From PMMA.
2/2015	Local bismuth thiols potentiate antibiotics and reduce infection in a contaminated open fracture model.
6/2014	Local antibiotic delivery by a bioabsorbable gel is superior to PMMA bead depot in reducing infection in an open fracture model.
10/2013	Effects of local delivery of D-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects.
12/2012	Comparison of the antimicrobial effect of chlorhexidine and saline for irrigating a contaminated open fracture model.

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Joseph C Wenke Research Topics

Disease

63	Wounds and Injuries (Trauma) 07/2022 - 10/2005
41	Infections 01/2022 - 01/2005
15	Open Fractures (Compound Fracture) 07/2022 - 12/2005
6	Wound Infection (Wound Infections) 12/2019 - 07/2009
5	Ischemia 01/2022 - 10/2015
5	Reperfusion Injury 01/2022 - 08/2013
5	Pain (Aches) 12/2015 - 10/2005
4	Hemorrhage 12/2019 - 10/2005
4	Persistent Infection 01/2018 - 06/2013
3	Multiple Trauma (Multiple Injuries) 02/2022 - 02/2019
3	Burns 02/2019 - 10/2012
2	Cicatrix (Scar) 08/2021 - 02/2013
2	Inflammation (Inflammations) 01/2021 - 02/2019
2	Bone Fractures (Bone Fracture) 01/2019 - 12/2011
2	Staphylococcal Infections 12/2018 - 01/2005
2	Invasive Fungal Infections 10/2018 - 08/2013
2	Coinfection 03/2018 - 04/2014
2	Hemorrhagic Shock 01/2018 - 10/2015
2	Edema (Dropsy) 01/2018 - 10/2015
2	Compartment Syndromes 10/2016 - 10/2015
2	Soft Tissue Injuries (Soft Tissue Injury) 10/2016 - 01/2010
2	Heterotopic Ossification (Ectopic Ossification) 10/2015 - 04/2014
1	Fibrosis (Cirrhosis) 01/2020
1	Communicable Diseases (Infectious Diseases) 12/2018
1	Fatigue 10/2018
1	Bacterial Infections (Bacterial Infection) 01/2018
1	Surgical Wound Infection 12/2017
1	Vascular System Injuries 10/2017
1	Blast Injuries 10/2016
1	Synostosis 04/2016
1	Periostitis 12/2015
1	Soft Tissue Infections 08/2015

Drug/Important Bio-Agent (IBA)

31	Anti-Bacterial Agents (Antibiotics)IBA 07/2022 - 12/2005
15	Vancomycin FDA LinkGeneric 07/2022 - 07/2009
8	Polymethyl Methacrylate (Sol)IBA 12/2020 - 08/2010
7	Saline SolutionIBA 07/2022 - 10/2006
6	SolutionsIBA 01/2022 - 10/2006
5	PowdersIBA 02/2021 - 10/2016
5	Bone Cements (Bone Glue)IBA 01/2021 - 01/2016
5	Rifampin (Rifampicin)FDA LinkGeneric 12/2018 - 08/2014
4	Pharmaceutical PreparationsIBA 08/2021 - 12/2011
4	CytokinesIBA 01/2021 - 03/2015
4	ChitosanIBA 03/2018 - 09/2010
4	Calcium Sulfate (Alabaster)IBA 01/2016 - 01/2005
3	HMGB1 Protein (HMG1)IBA 02/2022 - 02/2019
3	Oxygen (Dioxygen)IBA 01/2022 - 08/2011
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2018
3	Cefazolin (Ancef)FDA LinkGeneric 12/2019 - 08/2014
3	Tobramycin (Nebcin)FDA LinkGeneric 06/2014 - 01/2005
3	Explosive Agents (Explosives)IBA 01/2010 - 01/2006
2	Sodium Hypochlorite (Clorox)IBA 10/2018 - 12/2014
2	Virulence Factors (Pathogenicity Factors)IBA 01/2017 - 01/2013
2	Clindamycin (Cleocin)FDA LinkGeneric 01/2017 - 08/2014
2	Biological ProductsIBA 12/2015 - 12/2011
2	Amino Acids FDA Link 08/2014 - 10/2013
2	Gentamicins (Gentamicin)FDA LinkGeneric 06/2014 - 07/2009
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2011 - 07/2011
2	Amikacin (A.M.K)FDA LinkGeneric 09/2010 - 07/2009
1	Capsules (Microcapsules)IBA 07/2022
1	PalovaroteneIBA 08/2021
1	nintedanibIBA 01/2020
1	Ertapenem (Invanz)FDA Link 12/2019
1	Moxifloxacin (Avelox)FDA Link 12/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2019
1	Interleukin-6 (Interleukin 6)IBA 02/2019
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2019
1	GasotransmittersIBA 01/2019
1	Daptomycin FDA Link 12/2018
1	Tacrolimus (Prograf)FDA LinkGeneric 06/2017
1	norspermidineIBA 01/2017
1	Decellularized Extracellular MatrixIBA 11/2016
1	Voriconazole (Vfend)FDA LinkGeneric 12/2015
1	FluoridesIBA 12/2015
1	Ringer's LactateIBA 10/2015
1	Indomethacin (Indometacin)FDA LinkGeneric 10/2015
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/2015
1	RifamycinsIBA 09/2015
1	Therapeutic UsesIBA 03/2015

Therapy/Procedure

23	Therapeutics 01/2022 - 07/2009
12	Debridement 02/2021 - 07/2009
11	Surgical Amputation (Amputations) 01/2017 - 11/2010
6	Tourniquets 01/2022 - 10/2005
5	Negative-Pressure Wound Therapy 02/2021 - 09/2010
4	Treatment Delay 07/2022 - 08/2013
4	Resuscitation 01/2018 - 08/2011
3	Sutures (Suture) 06/2011 - 01/2005
2	Osteotomy 02/2019 - 06/2017
2	Aftercare (After-Treatment) 12/2017 - 09/2012
2	Fasciotomy 10/2016 - 01/2013
2	Bone Transplantation (Bone Grafting) 08/2010 - 12/2005
2	Operative Surgical Procedures 10/2006 - 12/2005
1	Oral Administration 08/2021
1	Bioreactors (Bioreactor) 10/2020
1	Immunomodulation 01/2020
1	Arthrodesis 12/2017
1	Spinal Fusion (Spondylosyndesis) 12/2017
1	Arthroplasty 10/2017
1	Lasers (Laser) 01/2017
1	Limb Salvage 08/2015
1	Injections 06/2015